GEO series
An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq
GSE303901
Homo sapiens
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
97 samples
2025/08/15
GPL34281GPL18573
Summary
We developed Direct-Capture Targeted Perturb-seq (DC-TAP-seq), a cost-effective and sensitive approach that integrates U6-driven guide RNA capture with TAP-seq, enabling high-throughput screening of thousands of E–G connections at lower read depth. We applied this method to perform unbiased enhancer screens in two human cell types, K562 and WTC11. Our dataset revealed novel classes of non-canonical cis-regulatory elements (CREs) that were under-sampled in previous CRISPRi screens
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Paper (PMID 41000760) ↗
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