Decoupling oxidative resilience from reprogramming to rejuvenate the RPE and restore vision [GSTA4_RNA-seq_1]
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 7 × Young vs 4 × Old vs 4 × Old-OSK vs 3 × Old-ControlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304038_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1298811 and SRA study SRP604848. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9141474 Young-rep1 Young
- GSM9141475 Young-rep2 Young
- GSM9141476 Young-rep3 Young
- GSM9141477 Young-rep4 Young
- GSM9141478 Young-rep5 Young
- GSM9141479 Young-rep6 Young
- GSM9141480 Young-rep7 Young
- GSM9141481 Old-rep1 Old
- GSM9141482 Old-rep2 Old
- GSM9141483 Old-rep3 Old
- GSM9141484 Old-rep4 Old
- GSM9141485 Old-Control-rep1 Old-Control
- GSM9141486 Old-Control-rep2 Old-Control
- GSM9141487 Old-Control-rep3 Old-Control
- GSM9141488 Old-OSK-rep1 Old-OSK
- GSM9141489 Old-OSK-rep2 Old-OSK
- GSM9141490 Old-OSK-rep3 Old-OSK
- GSM9141491 Old-OSK-rep4 Old-OSK
- GSE304040 Decoupling oxidative resilience from reprogramming to rejuvenate the RPE and restore vision [GSTA4_RNA-seq_3] 24 samples shares gsta4, rpe, reprogramming, decoupling, resilience, rejuvenate, oxidative, restore
- GSE304037 Decoupling oxidative resilience from reprogramming to rejuvenate the RPE and restore vision [GSTA4_ATAC-seq_1] 42 samples shares gsta4, rpe, reprogramming, decoupling, resilience, rejuvenate, oxidative, restore
- GSE308273 Synthetic oleanane triterpenoids reduce tumor growth and promote an anti-tumor immune response independent of cancer KEAP1-mutational status 24 samples shares rpe
- GSE283518 Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection 20 samples shares rpe
- GSE283089 MFRP in the retina is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific protein and lipid molecules 12 samples shares rpe
- GSE298195 Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging [Quantseq_cell] 12 samples shares rpe
- GSE279041 Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma 12 samples shares rpe
- GSE261183 Effects of adipocyte ablation on RPE/choroid complex in mice 10 samples shares rpe
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.