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HuR coordinates systemic aging through platelet infiltration.

GSE304047 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/22 Platform GPL24247
Summary
Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in systemic aging. In aged mice, the levels of platelet-secreted pro-inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in brain, liver, lung, kidney, and aortic root. The RNA-binding protein HuR/ELAVL1, a major regulator of RNA metabolism, promoted the production of PSPF in platelets. Platelet-specific deletion of HuR reduced the expression of PSPF in platelets, alleviated platelet infiltration in brain, liver, lung, kidney, and aortic root, and delayed systemic aging. By using single-nucleus sequencing, platelet-specific HuR ablation was found to alleviate p53 and pro-inflammatory signaling pathways in liver, lung, and brain tissues in aged mice. Our findings highlight a role of platelets in coordinating aging traits across organs.
Published in
HuR coordinates systemic aging through platelet infiltration
Liu C, Wang Y, Xia T et al. · Nature communications 2026 · PMID 42098101 · doi:10.1038/s41467-026-72481-x
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Also filed as BioProject PRJNA1298823 and SRA study SRP604775. Searching any of these in the dataset finder brings you back here.

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