MIF Nuclease Inhibition Protects CNS Neurons following Inflammation.
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatosNature neuroscience · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304068_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1298858 and SRA study SRP545704. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 26 samples.
How we read this: 10 replicated groups read from 27 sample titles; they account for 26 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8636255 E22Q CFA 1 E22Q CFA
- GSM8636256 E22Q CFA 2 E22Q CFA
- GSM8636257 E22Q D14 1 E22Q D14
- GSM8636258 E22Q D14 2 E22Q D14
- GSM8636259 E22Q D14 3 E22Q D14
- GSM8636260 WT CFA 1 WT CFA
- GSM8636261 WT CFA 2 WT CFA
- GSM8636262 WT D14 1 WT D14
- GSM8636263 WT D14 2 WT D14
- GSM8636264 WT D14 3 WT D14
- GSM9142608 CFA, PAANIB1, female, rep 1 CFA, PAANIB1, female,
- GSM9142609 CFA, PAANIB1, female, rep 2 CFA, PAANIB1, female,
- GSM9142610 CFA, Vehicle, female, rep 1 CFA, Vehicle, female,
- GSM9142611 CFA, Vehicle, female, rep 2 CFA, Vehicle, female,
- GSM9142612 EAE, PAANIB1, male, rep 1 EAE, PAANIB1, male,
- GSM9142613 EAE, PAANIB1, male, rep 2 EAE, PAANIB1, male,
- GSM9142614 EAE, PAANIB1, male, rep 3 EAE, PAANIB1, male,
- GSM9142615 EAE, PAANIB1, female, rep 1 EAE, PAANIB1, female,
- GSM9142616 EAE, PAANIB1, female, rep 3 EAE, PAANIB1, female,
- GSM9142617 EAE, PAANIB1, female, rep 2 EAE, PAANIB1, female,
- GSM9142618 EAE, Vehicle, male, rep 1 EAE, Vehicle, male,
- GSM9142619 EAE, Vehicle, male, rep 2 EAE, Vehicle, male,
- GSM9142620 EAE, Vehicle, male, rep 3 EAE, Vehicle, male,
- GSM9142621 EAE, Vehicle, female, rep 3 EAE, Vehicle, female,
- GSM9142622 EAE, Vehicle, female, rep 1 EAE, Vehicle, female,
- GSM9142623 EAE, Vehicle, female, rep 2 EAE, Vehicle, female,
- GSM9142624 Unassigned Reads, rep 1
- GSE332759 Intracellular complement factor H protects neurons during CNS inflammation [bulkRNA-seq] 16 samples shares cns, protects, neurons
- GSE295974 Single-cell multi-omics reveal coordinated neoplastic and immune remodeling following KRAS inhibition 64 samples shares inhibition, following
- GSE322775 Coordinated immune activation following KRAS inhibition reveals molecular pathways that potentiate and limit anti-tumor immunity 47 samples shares inhibition, following
- GSE306012 Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction 28 samples shares inhibition, following
- GSE311963 CD38 endows local antigen-specific Foxp3+ Treg cells with stress resilience for compartmentalized control of CNS inflammation 68 samples shares cns
- GSE265833 Single cell RNA sequencing reveals limited effects of Lrrk2 genotype in a mouse model of acute CNS inflammation 18 samples shares cns
- GSE308884 CNS-penetrant NLRP3 inhibitor TN-783 achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity 18 samples shares cns
- GSE249687 Three-dimensional chromatin architecture in DRG neurons following sciatic nerve injury in WT and Rad21 KO mice. 52 samples shares following, neurons
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.