GEO series
Intracellular complement factor H protects neurons during CNS inflammation [bulkRNA-seq]
GSE332759
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/07/28
GPL24247
Summary
Complement factor H (CFH) has been implicated in neuroprotection during inflammatory neurodegeneration, but its neuron-intrinsic functions remain poorly understood. Here, we performed bulk RNA sequencing of primary neuronal cultures from Cfh conditional knockout (Cfh-cKO) and control mice under basal conditions or following glutamate-induced oxidative stress. This dataset was generated to characterize transcriptional changes associated with neuronal Cfh deficiency and to identify pathways regulated by intracellular CFH during neuronal stress responses.
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