Intracellular complement factor H protects neurons during CNS inflammation [bulkRNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE332759_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1469039 and SRA study SRP702623. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9753005 Bioreplicate 1 Cfh KO control
- GSM9753006 Bioreplicate 1 Cfh KO glutamate
- GSM9753007 Bioreplicate 1 wildtype control
- GSM9753008 Bioreplicate 1 wildtype glutamate
- GSM9753009 Bioreplicate 2 Cfh KO control
- GSM9753010 Bioreplicate 2 Cfh KO glutamate
- GSM9753011 Bioreplicate 2 wildtype control
- GSM9753012 Bioreplicate 2 wildtype glutamate
- GSM9753013 Bioreplicate 3 Cfh KO control
- GSM9753014 Bioreplicate 3 Cfh KO glutamate
- GSM9753015 Bioreplicate 3 wildtype control
- GSM9753016 Bioreplicate 3 wildtype glutamate
- GSM9753017 Bioreplicate 4 Cfh KO control
- GSM9753018 Bioreplicate 4 Cfh KO glutamate
- GSM9753019 Bioreplicate 4 wildtype control
- GSM9753020 Bioreplicate 4 wildtype glutamate
- GSE304068 MIF Nuclease Inhibition Protects CNS Neurons following Inflammation. 27 samples shares cns, protects, neurons
- GSE280505 Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche. 16 samples shares cns, factor
- GSE225367 GPR124 regulates murine CNS angiogenesis and blood-brain barrier formation by an intracellular domain-independent mechanism 12 samples shares cns, intracellular
- GSE298597 CNS infiltration by Tet2-mutant peripheral myeloid cells protects from Alzheimer’s Disease 12 samples shares cns, protects
- GSE244474 T cell - DAM feedback loop drives CNS inflammation and neurodegenration in SPG15 at an early age via CCR5-CCL5 interaction [CD3+] 1135 samples shares cns
- GSE287251 Adipose-derived Leptin and Complement Factor D mediate osteoarthritis severity and pain 17 samples shares complement, factor
- GSE333999 The intracellular domain of the epilepsy protein PCDH19 regulates spine density in cortical neurons in vivo via Xlr genes. 12 samples shares intracellular, neurons
- GSE311963 CD38 endows local antigen-specific Foxp3+ Treg cells with stress resilience for compartmentalized control of CNS inflammation 68 samples shares cns
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.