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Transcript changes in human pericytes exposed to Clostridioides difficile TcdB and an Hippo signaling inhibitor.

GSE304120 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/11 Platform GPL30173
Summary
These experiments are designed to profile of how TcdB and XMU-MP-1 modify gene expression in pericytes. TcdB is a bacterial toxin and primary virulence factor produced by the enteric pathogen C. difficile, and pericytes are putative target cells for TcdB in the colon. XMU-MP-1 is an inhibitor of a core kinase (MST1/2) in the Hippos signaling pathway, and TcdB activates Hippo signaling, which is possibly critical for the pathogenesis of C. difficile disease. RNA-seq was carried out and the resulting gene expression profiles were analyzed focusing on CSPG4 (TcdB receptor) and a panel of genes that are regulated by YAP and TAZ (primary transcriptional regulator in Hippo pathway). We also focused on genes regulated by MTF1, which is another transcription regulator that can be controlled by Hippo signaling.
Published in
Clostridioides difficile TcdB induces expression of its receptor (CSPG4) through a noncanonical Hippo signaling mechanism
Larabee JL, Donald EJ, Sukhadia AA et al. · The Journal of biological chemistry 2026 · PMID 41513094 · doi:10.1016/j.jbc.2026.111137
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Also filed as BioProject PRJNA1299296 and SRA study SRP605773. Searching any of these in the dataset finder brings you back here.

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