Activation of the aryl hydrocarbon receptor in human melanoma cells enhances cancer cell-intrinsic MHC-II expression [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 9 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 9 samples: 3 × A375 Control ATAC vs 3 × A375 AHRKO ATAC vs 3 × A375 ARNTKO ATACGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanomaJournal of experimental & clinical cancer research : CR · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304147_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1285589 and SRA study SRP597947. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9144350 A375 Control ATAC Rep 1 A375 Control ATAC
- GSM9144351 A375 Control ATAC Rep 2 A375 Control ATAC
- GSM9144352 A375 Control ATAC Rep 3 A375 Control ATAC
- GSM9144353 A375 AHRKO ATAC Rep 1 A375 AHRKO ATAC
- GSM9144354 A375 AHRKO ATAC Rep 2 A375 AHRKO ATAC
- GSM9144355 A375 AHRKO ATAC Rep 3 A375 AHRKO ATAC
- GSM9144356 A375 ARNTKO ATAC Rep 1 A375 ARNTKO ATAC
- GSM9144357 A375 ARNTKO ATAC Rep 2 A375 ARNTKO ATAC
- GSM9144358 A375 ARNTKO ATAC Rep 3 A375 ARNTKO ATAC
- GSE305296 Activation of the aryl hydrocarbon receptor in human melanoma cells enhances cancer cell-intrinsic MHC-II expression 43 samples shares mhc-ii, cell-intrinsic, hydrocarbon, activation, receptor, melanoma, enhances
- GSE279781 CD137 agonism enhances anti-PD1 induced activation of clonally expanded CD8+ T cells in a neoadjuvant pancreatic cancer clinical trial 30 samples shares activation, enhances
- GSE324815 Intratumoral CD40 agonist sotigalimab in combination with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: Results of a phase 1/2 study 24 samples shares activation, melanoma
- GSE311565 Disordered protein LAT encodes relative levels of signaling pathways in T cell activation [Perturb-ATAC-seq] 18 samples shares activation, atac-seq
- GSE300717 RNA-seq and ATAC-seq analysis of 5-azacytidine-treated HepG2 cells reveals epigenetic reactivation of BFL-1 and SQOR in hepatocellular carcinoma 17 samples shares activation, atac-seq
- GSE301741 Single cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma 58 samples shares mhc-ii
- GSE339049 Severe long-COVID is driven by monocyte reprogramming and broad immune dysregulation linked to herpesvirus activation 48 samples shares activation
- GSE264550 Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer 25 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.