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KIRA6 abrogates the generation of myeloid-derived suppressor cells and overcomes resistance to anti-PD-1 therapy

GSE304255 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/06 Platform GPL24247
Summary
Immune checkpoint blockade (ICB) therapy is one of the cornerstones of cancer treatment regimens in a broad range of cancers nowadays, but the overall response rates remain low as a result of alternative immunosuppressive immune cells, such as myeloid-derived suppressor cells (MDSCs). Therefore, it is unmet need to target MDSCs in the tumor microenvironment to achieve better outcome of ICB therapy. Inositol-requiring enzyme 1α (IRE1α) is identified as a key regulator for generation of MDSC. Here, we evaluated the potential of KIRA6, an inhibitor for IREα kinase activity and RNase activity, to abrogate MDSC mediated immune suppression and improve outcome of ICB therapy.
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Direct links to NCBI, no account and no request form: the whole study as GSE304255_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1299547 and SRA study SRP605641. Searching any of these in the dataset finder brings you back here.

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