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RNA sequencing of aortic valves from dialysis and non-dialysis patients with aortic stenosis

GSE304300 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/12 Platform GPL24676
Summary
Patients with aortic stenosis (AS) undergoing hemodialysis (HD) often experience faster disease progression and poorer prognosis than non-dialysis patients, yet the underlying mechanisms remain unclear. This study aimed to elucidate clinical and molecular differences between HD and non-HD patients with AS, focusing on transcriptomic profiling of resected aortic valves.
Published in
Clinical and Transcriptomic Characteristics of Aortic Stenosis in Patients Undergoing Haemodialysis
Shiraiwa S, Tran NQV, Watanabe Y et al. · Interdisciplinary cardiovascular and thoracic surgery 2026 · PMID 41507096 · doi:10.1093/icvts/ivag008
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Direct links to NCBI, no account and no request form: the whole study as GSE304300_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1300329 and SRA study SRP605791. Searching any of these in the dataset finder brings you back here.

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