GEO series
Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [CUT&Tag]
GSE304392
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/08/05
GPL28330
Summary
Fatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis.Inhibition of long-chain fatty acid β-oxidation (LCFAO) results in preimplantation developmental arrest, downregulated expressions of S phase-related genes, and loss of H3K18ac modification. By profiling the landscape of H3K18ac, we show that H3K18ac is enriched on the promoter regions of S phase-related genes and correlates with their expression. Taken together, we demonstrate that LCFAO could regulate mouse preimplantation development by H3K18ac, providing new evidence for metabolic-epigenetic crosstalk in regulating embryonic development.
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Paper (PMID 41415208) ↗
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