Therapeutic targeting of lipidated amino acid deficiency ameliorates MASH via a PPARα/CCL2 axis
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × Male CD vs 3 × Male MASH vs 3 × Male MASH OA vs 2 × Male MASH OALGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304787_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1302526 and SRA study SRP607109. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9157288 Male CD 1 Male CD
- GSM9157289 Male CD 2 Male CD
- GSM9157290 Male CD 3 Male CD
- GSM9157291 Male CD 4 Male CD
- GSM9157292 Male MASH 2 Male MASH
- GSM9157293 Male MASH 3 Male MASH
- GSM9157294 Male MASH 4 Male MASH
- GSM9157295 Male MASH OA 1 Male MASH OA
- GSM9157296 Male MASH OA 2 Male MASH OA
- GSM9157297 Male MASH OA 3 Male MASH OA
- GSM9157298 MaleMASH OA 4
- GSM9157299 Male MASH OAL 1 Male MASH OAL
- GSM9157300 Male MASH OAL 2 Male MASH OAL
- GSM9157301 MaleMASH OAL 4
- GSE301751 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 7/9) 53 samples shares mash, therapeutic
- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares mash, ameliorates
- GSE310507 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 6) 24 samples shares mash, therapeutic
- GSE255321 Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice 24 samples shares mash, therapeutic
- GSE286997 FGF2 Mediated USP42-PPAR Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration 12 samples shares ppar, ameliorates
- GSE280725 Adipose-specific MTP deficiency protects against hepatic steatosis up upregulating PPARα activity 10 samples shares ppar, deficiency
- GSE248272 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer 30 samples shares therapeutic, targeting
- GSE308848 Targeting AEBP1 to mitigate pro-tumor activity of cancer-associated fibroblasts and increase therapeutic efficacy to anti-PD-1 [scRNA-Seq] 12 samples shares therapeutic, targeting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.