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Smoking promotes the progression of colorectal cancer via CKAP2L/STAT3/AREG/EGFR axis

GSE305039 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/20 Platform GPL16791
Summary
Smoking is a major risk factor for colorectal cancer (CRC). But the underlying molecular mechanisms by which smoking promotes CRC remain unclear. The positive association between smoking and CRC was confirmed by both cross-sectional study and mendelian randomization analyses. RNA-seq sequencing and bioinformatics analysis were conducted to identify the key genes involved in smoking-induced CRC progression. After treatment with cigarette smoke extract (CSE) in CRC cells, cell proliferation and metastasis were enhanced. Subsequently, we isolated the total RNA of HCT116 cells treated with CSE and subjected it to the RNA-seq to explore the differentially expressed genes.
Published in
Smoking promotes colorectal cancer via the CKAP2L/AREG axis
Wu S, Wu F, Li X et al. · International journal of oncology 2026 · PMID 41823522 · doi:10.3892/ijo.2026.5872
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Also filed as BioProject PRJNA1304274 and SRA study SRP607990. Searching any of these in the dataset finder brings you back here.

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