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scRNA-seq Analysis of Dmp1cre-DTAki/wt and wt skin

GSE305068 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/15 Platform GPL24247
Summary
Utilizing the 10X Genomics Cell Ranger (Pipeline Version 3.1.0) platform, this study investigates the impact of osteocyte ablation on ​​skin aging​​. Skin and bone share significant structural and molecular homology, including compositional architecture, cellular origins, and signaling pathways. Both tissues exhibit parallel degenerative changes during natural aging and under pathological conditions, characterized by collagen depletion leading to osteoporosis and skin atrophy. Through scRNA-seq analysis of skin following osteocyte knockout, our research provides novel insights into the regulatory role of osteocytes in ​​skin aging​​.
Published in
Osteolineage cells ablation promotes skin aging phenotypes via dysregulated bone marrow macrophages
Zhang SY, Zheng ZK, Ye F et al. · iScience 2026 · PMID 41797915 · doi:10.1016/j.isci.2026.114888
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Also filed as BioProject PRJNA1304389 and SRA study SRP608244. Searching any of these in the dataset finder brings you back here.

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