GEO series

Genome-wide occupancy of RORB in neuroblastoma cells.

GSE305134 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/12/10 Platform GPL20795

Summary

Neuroblastoma (NB), a malignant embryonic tumor arising from primitive neural crest cells, accounts for more than 7% of malignancies and around 15% of cancer-related mortality in childhood. Better elucidating the mechanisms of tumorigenesis and aggressiveness is important for improving the therapeutic efficiencies of NB. To investigate the mechanisms underlying the tumor suppressive functions of RAR-related orphan receptor B (RORB), we employed the Illumina HiSeq X Ten as a discovery platform to analyze the genome-wide occupancy of RORB on target genes in human SK-N-BE(2) cells. The results showed that 1637 target genes were regulated by transcriptional regulator RORB, especially those involved in regulation of NF-κB signaling pathway. Furthermore, we validated the ChIP-seq results by real-time PCR with high identity. Overall, our results provided fundamental information about the genomic enrichment of RORB in human NB cells, and these findings will help us understand the pathogenesis of NB.

Published in

Targeting RBM10-Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF-κB Signaling

Guo Y, Wang X, Yang C et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40899609 · doi:10.1002/advs.202506131

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Direct links to NCBI, no account and no request form: the whole study as GSE305134_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1304491 and SRA study SRP608215. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40899609) ↗

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