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Effect of Sox2-activation on transcriptomic profiles of murine lung tumors

GSE305193 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/16 Platform GPL34290
Summary
To investigate the effect of Sox2-activation during lung tumorigenesis, we treated CRISPRa competent PPKS (KRAS(LSL-G12D//wt); TP53(flox/flox); Rosa26(LSL-SAM/wt)) mice with CMV-Cre/U6-sgRNA(MS2) encoding lentivirus carrying Sox2-targeted or non-targeted sgRNA. Tumors were harvested at survival endpoint and transcriptomic reprogramming was assessed with RNA-seq.
Published in
An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection
Thege FI, Hoskins A, Kramer A et al. · Cell reports. Medicine 2026 · PMID 41999750 · doi:10.1016/j.xcrm.2026.102759
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Also filed as BioProject PRJNA1304567 and SRA study SRP608179. Searching any of these in the dataset finder brings you back here.

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