GEO series
Carbonic Anhydrase 12 is a Novel Prognostic Biomarker and Therapeutic Target for High-Risk Follicular Thyroid Cancer
GSE305211
Homo sapiens
Expression profiling by high throughput sequencing
19 samples
2026/01/14
GPL24676GPL34284
Summary
Identifying high-risk follicular thyroid cancer (FTC) is critical for stratified treatment and developing targeted therapies. This study performed RNA sequencing on high-risk FTC, identifying Carbonic Anhydrase 12 (CA12) as a promising biomarker. High CA12 expression predicted poor disease-free survival, surpassing conventional markers. In vitro, CA12 knockdown reduced proliferation and invasion, while a CA12 inhibitor showed synergistic anti-proliferative effects with Lenvatinib. These findings establish CA12 as both a novel prognostic biomarker and a potential therapeutic target for FTC.
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Paper (PMID 41208415) ↗
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