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Human Placenta–Derived Mesenchymal Stem Cells Attenuate Hippocampal Aging-Associated Transcriptomic Profiles in Aged Mice

GSE305309 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/03 Platform GPL13112
Summary
Background Intravenous human placenta–derived mesenchymal stem cells (hpMSCs) can improve tissue function through paracrine effects, but their impact on normal brain aging is not well defined. Methods Aged female mice (18–19 months) received three intravenous infusions of hpMSCs or PBS at six-week intervals. Hippocampal tissue was collected after the behavioral tests for RNA sequencing. Results RNA sequencing showed hpMSCs' effectiveness in modulating aging-related neural pathways, particularly by downregulating age-specific genes in the hippocampus, indicative of neural reactivation. Conclusions Systemic hpMSC administration modulates neural pathways in aged mice.
Published in
Mesenchymal stem cell derived extracellular vesicles reverses neural aging via OSKM modulation
Kim C, Nam SH, Park JH et al. · Cell communication and signaling : CCS 2025 · PMID 41162985 · doi:10.1186/s12964-025-02469-5
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Also filed as BioProject PRJNA1305228 and SRA study SRP608580. Searching any of these in the dataset finder brings you back here.

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