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LincRNA-EPS regulates iron metabolism and osteoclastogenesis under inflammatory micro-environment

GSE305332 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/18 Platform GPL34290
Summary
This study aims to investigate the impact of LincRNA-EPS on osteoclast lineage differentiation. We established LincRNA-EPS gene knockout mice on the C57BL/6 background and isolated bone marrow-derived macrophages (BMDMs) from both knockout and wild-type mice. These BMDMs were induced with RANKL in vitro for 2 days to generate pre-osteoclast cells. Transcriptome sequencing was performed on these cells, followed by further analysis of differentially expressed genes to explore the effects of LincRNA-EPS deficiency on osteoclast differentiation in BMDMs.​ In this study, we found that dysregulated osteoclastogenesis and iron homeostasis without lincRNA-EPS, represented by up-regulated gene Lcn2.
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Also filed as BioProject PRJNA1305314 and SRA study SRP608664. Searching any of these in the dataset finder brings you back here.

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