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Control samples for study "hiv-seq reveals global host gene expression differences between hiv-transcribing cells from viremic and suppressed people with hiv"

GSE305352 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/10 Platform GPL24676
Summary
In our study, we aimed to improve the identification of active reservoir cells producing HIV in individuals undergoing antiretroviral therapy (ART). We developed a technique called HIV-Seq to enhance the efficiency of capturing HIV transcripts during single-cell RNA sequencing (scRNAseq) analysis. By applying this technique, we compared the transcriptional features of HIV RNA+ cells before and after ART initiation. Our findings highlight distinct transcriptional signatures of active reservoir cells during viremia and suppression, demonstrating the utility of HIV-Seq in elucidating the mechanisms underlying reservoir persistence during ART.
Published in
HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV
Frouard J, Telwatte S, Luo X et al. · Nature communications 2026 · PMID 41776157 · doi:10.1038/s41467-026-68797-3
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Direct links to NCBI, no account and no request form: the whole study as GSE305352_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1305386 and SRA study SRP608725. Searching any of these in the dataset finder brings you back here.

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