miR-4711-5p suppresses the cancer stemness, proliferation and invasion activity in pancreatic cancer

Background/Aim: Pancreatic cancer is a highly malignant neoplasm and current treatment options have only shown minimal efficacy. Therefore, pancreatic cancer continues to have a poor prognosis, with the lowest 5-year survival rate and the development of efficient cancer therapeutics is desired. MiRNAs are involved in post-transcriptional regulation of gene expression and expected as a next generation cancer therapy. Here, we investigated the anti-tumor effects of miR-4711-5p in pancreatic cancer cells. Materials and Methods: We investigated the effects of miR-4711-5p treatment on cell proliferation, cell cycle, apoptosis, cancer stemness, and invasion in pancreatic cancer cell lines. We also explored the novel target genes of miR-4711-5p in RNA sequencing and in silico analysis. Results: We showed that miR-4711-5p suppressed cancer stemness, cell proliferation, and invasion and induced cell cycle delay and apoptosis in pancreatic cancer cells. MET, CASTA, and ANO1 were identified as potential target genes of miR-4711-5p. Conclusion: miR-4711-5p are potential therapeutic miRNAs in pancreatic cancer cells.