GEO series
m6A epitranscriptome regulates axonogenesis and reprogramming of retinal ganglion cells [RNA-seq]
GSE305554
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/02/24
GPL24247
Summary
induced retinal ganglion cells (iRGCs) is an excellent system to generate RGC-like neurons for translational and theoretical studies. N6-methyladenosine (m6A) is the most prevalent internal modification in mRNAs. Using this iRGC system, we demonstrated that Mettl3, the core component of the m6A-methyltransferase complex, promotes iRGC axon development and the final iRGC reprogramming outcome.
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Paper (PMID 41791385) ↗
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