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The Colon Contains an Immature/Intermediate iNKT Cell Population That is Expandable by CD1d Expressing Goblet Cells and Can be Protective in Colitis

GSE306154 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/26 Platform GPL34328Platform GPL34281
Summary
scRNA-seq from sorted murine and human colonic iNKT populations to determine subsets compared to published human thymic data. For murine samples mice were treated with EGFRi or vehicle for 4 days prior to sort.
Published in
CD1d+ Goblet Cells Expand Colon-Resident Immature, Intermediate and Differentiated iNKT Cells to Limit Colitis
John V, Barrios B, Wang JD et al. · Research square 2025 · PMID 41041542 · doi:10.21203/rs.3.rs-7603392/v1
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Also filed as BioProject PRJNA1309594 and SRA study SRP610732. Searching any of these in the dataset finder brings you back here.

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