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Gene expression prolife at single cell level of cells in the pre-metastatic niche liver with WT or hepatocytes LRG1 knockout

GSE306164 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/15 Platform GPL34290
Summary
We injected MC38 colorectal cancer cells in situ in WT and hepatocyte LRG1 KO mice, thereby establishing the pre-metastatic microenvironment in the liver. Then, livers in different group were subjected to digestion and single-cell sequencing.
Published in
Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy
Long G, Cheng B, Jiang Y et al. · Cellular & molecular immunology 2026 · PMID 41963620 · doi:10.1038/s41423-026-01408-9
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Also filed as BioProject PRJNA1309623 and SRA study SRP610739. Searching any of these in the dataset finder brings you back here.

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