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IRS2 Promotes Proliferation and Drives Invasion-Migration in SI-NETs.

GSE306367 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/26 Platform GPL24247
Summary
I investigated the role of insulin receptor substrate 2 (IRS2) in small-intestinal neuroendocrine tumours (SI-NETs). Using SI-NET cell lines (STC-1 and Glu-tag), I found that IRS2 was significantly upregulated. IRS2 knockdown inhibited cellular proliferation, migration, and invasion, while its overexpression promoted these processes. For in vivo validation, I established stable IRS2-knockdown cell lines and performed xenograft experiments in nude mice. Transcriptomic profiling by RNA sequencing was conducted to identify downstream targets of IRS2 signaling.
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Also filed as BioProject PRJNA1310538 and SRA study SRP612461. Searching any of these in the dataset finder brings you back here.

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