← BioTransfer GEO Dataset Finder
GEO series

Identification RBPMS2 as a key regulator in mouse early oocyte development

GSE306544 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/16 Platform GPL24247
Summary
In the process of follicle formation, oocyte stably maintain large number of RNAs for development. However, how mammalian oocytes regulate these mRNAs, especially in the early oocyte, is unclear. We focused on RNA-binding proteins and identified RBPMS2 as a key factor in this process. Genetic disruption Rbpms2 causes female mouse infertility due to primordial oocyte defect. Transcriptome and RIP-seq analysis revealed that RBPMS2 binds 3′ UTR region to stabilize mRNAs of known oogenesis regulators, such as Lhx8. RBPMS2 also targets transcripts regulating cytoskeleton and cellular trafficking, such as Clasp1 and Rab27a, which are down-regulated in knock out oocytes. Rbpms2 knock out induces impairments in endocytosis and the accumulation of mitochondria and Golgi bodies in primordial oocyte. In summary, our study reveals RBPMS2 regulates mouse oogenesis through stabilizing mRNAs regulating oocyte development cellular trafficking and organelle enrichment, connecting post-transcriptional regulation to organelles accumulation and early oocyte development.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE306544_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1311095 and SRA study SRP612764. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.