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Transcriptome analysis of early human placenta and idiopathic recurrent pregnancy loss samples

GSE306548 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/15 Platform GPL24676
Summary
The goal of this study was to test gene expression changes in developing human placenta, which are associated with idiopathic recurrent pregnancy losses (RPL). In particular, we focused on RPL placental tissues that show significant defect in villi organization. Placental samples (less that 15 weeks) were collected. 4 control placentae with normal villi structure and 4 RPL placentae with defective villi formation were collected and ensured tissue viability. Whole placental villi were used to prepare RNA using Qiagen RNeasy Mini Kit with on column DNase digestion. RNA-seq analysis were performed using a NovaSeq 6000 platform.
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Direct links to NCBI, no account and no request form: the whole study as GSE306548_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1311103 and SRA study SRP613013. Searching any of these in the dataset finder brings you back here.

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