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Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [RNA-Seq]

GSE306753 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/14 Platform GPL24247
Summary
Tau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD) (ref). Neuron death is one of the hallmarks of neurodegeneration (ref). However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remains elusive. Here we demonstrated the essential role of neuron death in Tau-related neurodegeneration. Tau-neurons died in necroptosis, dependent on ZBP1 sensitized by Z-RNAs (an unusual left-handed conformation). Those endogenous Z-RNAs were transcripts of reactivated transposable elements (TEs) originally silenced in heterochromatin.
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Also filed as BioProject PRJNA1312045 and SRA study SRP613974. Searching any of these in the dataset finder brings you back here.

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