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FABP4 Contributes to Preeclampsia Through Dysregulating Lipid Metabolism and Inducing Mitochondrial Oxidative Stress in Trophoblasts

GSE306887 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/25 Platform GPL24676
Summary
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder characterized by abnormal placental development and systemic endothelial dysfunction. Previous studies have suggested that fatty acid binding protein 4 (FABP4) is involved in lipid metabolism and oxidative stress regulation in various metabolic and cardiovascular diseases. However, its specific role and underlying mechanisms in PE, particularly in trophoblast function and mitochondrial homeostasis, remain unclear. This study aims to investigate the role of FABP4 in the pathogenesis of PE by exploring its effects on trophoblast cell function and mitochondrial oxidative stress through regulating lipid metabolism.
Published in
FABP4 is highly expressed in preeclamptic placentas and regulates trophoblast lipid metabolism, mitochondrial function, and oxidative stress in vitro
Sun H, Wang Q, Wu L et al. · BMC pregnancy and childbirth 2026 · PMID 41664057 · doi:10.1186/s12884-026-08789-9
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Also filed as BioProject PRJNA1312857 and SRA study SRP614797. Searching any of these in the dataset finder brings you back here.

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