The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × MuSCs, Adult, DMSO, vs 4 × MuSCs, Aged, DMSO, vs 3 × MuSCs, Aged, ISR-a,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo RegenerationbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306935_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1314012 and SRA study SRP616582. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9212752 MuSCs, Adult, DMSO, 1 MuSCs, Adult, DMSO,
- GSM9212754 MuSCs, Adult, DMSO, 2 MuSCs, Adult, DMSO,
- GSM9212756 MuSCs, Adult, DMSO, 3 MuSCs, Adult, DMSO,
- GSM9212758 MuSCs, Adult, DMSO, 4 MuSCs, Adult, DMSO,
- GSM9212760 MuSCs, Aged, DMSO, 1 MuSCs, Aged, DMSO,
- GSM9212762 MuSCs, Aged, DMSO, 2 MuSCs, Aged, DMSO,
- GSM9212763 MuSCs, Aged, DMSO, 3 MuSCs, Aged, DMSO,
- GSM9212764 MuSCs, Aged, DMSO, 4 MuSCs, Aged, DMSO,
- GSM9212765 MuSCs, Aged, ISR-a, 1 MuSCs, Aged, ISR-a,
- GSM9212766 MuSCs, Aged, ISR-a, 2 MuSCs, Aged, ISR-a,
- GSM9212767 MuSCs, Aged, ISR-a, 3 MuSCs, Aged, ISR-a,
- GSM9212768 MuSCs, Aged, ISR-a 4
- GSE263688 Ageing promotes metastasis via activation of the integrated stress response 16 samples shares integrated, activation, stress
- GSE247504 Sustained NF-kB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation [Expt2] 10 samples shares regeneration, activation, stem
- GSE329069 Deletion of P311 enhances regeneration in aged skeletal muscle 9 samples shares regeneration, muscle, aged
- GSE250460 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells 20 samples shares activation, muscle, stem
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation, muscle
- GSE226579 Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration [RNA-seq] 47 samples shares regeneration, stem
- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares activation, improves
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares activation, stem
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.