Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cellsNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250460_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1054099 and SRA study SRP478628. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 8 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7979387 Keap1-null, Input, bench 1 Keap1-null, Input, bench
- GSM7979388 Keap1-null, Nrf2, ChIP, bench 1 Keap1-null, Nrf2, ChIP,…
- GSM7979389 Nrf2-null, Input, bench 1 Nrf2-null, Input, bench
- GSM7979390 Nrf2-null, Nrf2, ChIP, bench 1 Nrf2-null, Nrf2, ChIP, …
- GSM7979391 Keap1-null, Input, bench 2 Keap1-null, Input, bench
- GSM7979392 Keap1-null, Nrf2, ChIP, bench 2 Keap1-null, Nrf2, ChIP,…
- GSM7979393 Nrf2-null, Input, bench 2 Nrf2-null, Input, bench
- GSM7979394 Nrf2-null, Nrf2, ChIP, bench 2 Nrf2-null, Nrf2, ChIP, …
- GSM7979395 freshly isolate, female, keap1 Hetz164 freshly isolate, female…
- GSM7979396 freshly isolate, female, keap1 Hetz165 freshly isolate, female…
- GSM7979397 freshly isolate, female, keap1 Hetz181 freshly isolate, female…
- GSM7979398 freshly isolate, female, keap1 KO166 freshly isolate, female…
- GSM7979399 freshly isolate, female, keap1 KO178 freshly isolate, female…
- GSM7979400 freshly isolate, female, keap1 KO188 freshly isolate, female…
- GSM7979401 freshly isolate, male, keap1 Hetz204 freshly isolate, male, …
- GSM7979402 freshly isolate, male, keap1 Hetz245 freshly isolate, male, …
- GSM7979403 freshly isolate, male, keap1 Hetz249 freshly isolate, male, …
- GSM7979404 freshly isolate, male, keap1 KO240 freshly isolate, male, …
- GSM7979405 freshly isolate, male, keap1 KO247 freshly isolate, male, …
- GSM7979406 freshly isolate, male, keap1 KO255 freshly isolate, male, …
- GSE255927 Differential squamous cell fates elicited by NRF2 gain-of-function versus KEAP1 loss-of-function 25 samples shares keap1, nrf2
- GSE224756 Redox sensor KEAP1 promotes stemness and prevents reductive stress in exhausted CD8+ T cells via inhibiting NRF2 18 samples shares keap1, nrf2
- GSE266024 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury 42 samples shares nrf2, activation
- GSE299332 NRF2 Activation in Cancer Cells Suppresses Immune Infiltration into Tumor Microenvironment 28 samples shares nrf2, activation
- GSE266022 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [ChIP-seq] 24 samples shares nrf2, activation
- GSE246877 Steroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress 12 samples shares nrf2, activation
- GSE275142 The Fosl1-Kdm6b Axis Controls Skeletal Muscle Fibrosis by Regulating Histone H3K27me3 [Cut&Tag] 24 samples shares regulating, muscle
- GSE275143 The Fosl1-Kdm6b Axis Controls Skeletal Muscle Fibrosis by Regulating Histone H3K27me3 [HiCAR] 12 samples shares regulating, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.