Vitamin B12 Ameliorates Diabetic complications: potential role of Circadian pathway and the NAMPT–NAD⁺–SIRT1 Pathway
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Vitamin B12 Protects Against Early Diabetic Kidney Injury and Alters Clock Gene Expression in MiceBiomolecules · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306999_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1314101 and SRA study SRP616677. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE304351 NAD+ enhanced mesenchymal stromal cells effect on muscle atrophy by improving SIRT1/PGC-1α-mediated mitochondrial function via NAMPT 8 samples shares nampt, sirt1, nad
- GSE152067 Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically-unhealthy lean phenotype in female mice during aging 16 samples shares nampt, nad
- GSE306603 NMN protects cisplatin induced AKI via NAD+/SIRT1 pathway 8 samples shares sirt1, nad
- GSE331168 NAD+ deficiency enhances mitochondria-endoplasmic reticulum contacts to promote stress urinary incontinence via the Sirt1-MFN2 axis 6 samples shares sirt1, nad
- GSE64379 The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells 28 samples shares sirt1, nad
- GSE55485 Defective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration (mouse) 12 samples shares sirt1, nad
- GSE240483 NAD+ controls circadian rhythmicity during cardiac aging 30 samples shares nad, circadian
- GSE273289 Inhibiting hepatic LPCAT3 ameliorates alcoholic liver injury through regulating NAMPT and PTLP signaling 12 samples shares nampt, ameliorates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.