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BOLL-containing Aggregate Mediates Translational Regulation During Human Oogenesis

GSE307299 Homo sapiens (human) RNA-seq (gene expression) 14 samples Submitted 2026/04/15 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 14 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
BOLL-Containing Aggregates Mediate the Translational Regulation During Human OogenesisCell proliferation · 2026
Summary (written by the submitters)
Human oocyte meiosis utilizes a specialized translational control strategy to coordinate meiotic progression, mediated through dynamic regulation of mRNA stores. While germ cell-specific RNA-binding proteins (RBPs) are known to orchestrate this post-transcriptional program, the mechanistic basis of RBP-mediated cell fate specification remains elusive.
Read the full summary ↓
Here, we demonstrate that BOLL, a Deleted in Azoospermia (DAZ) family protein, forms protein aggregates during meiotic prophase to drive translational reprogramming in human oogenesis. We determined that BOLL enhance translation efficiency of cell cycle regulators, as demonstrated by integrative translatome-transcriptome analysis combined with RNA immunoprecipitation sequencing. We also revealed the functional interaction network of BOLL with core translation machinery components through its conserved DAZ containing domain. Crucially, we identified the SDS-resistant protein aggregates as BOLL structural signature in human oocyte-like cells, demonstrated by semi-denaturing electrophoretic analysis. These finding delineate a protein aggregate-mediated regulatory paradigm where BOLL aggregates exert spatiotemporal control over cell cycle related genes during the meiotic prophase of human oogenesis.
Published in
BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis
Li Y, Mao L, Liang B et al. · Cell proliferation 2026 · PMID 41742712 · doi:10.1111/cpr.70181
This dataset
Open GSE307299 in finder → Find more human datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307299_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1315168 and SRA study SRP617640. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41742712) ↗
Study design
7 conditions, mostly in duplicate
Ribo_BOLL ×2 Ribo_Control ×2 RNA_BOLL ×2 RNA_Control ×2 BOLL ×2 IgG ×2 Input ×2

Supports a between-group comparison across 14 samples.

How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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