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Cardio-immune Interaction via a Clusterin-TLR4 Axis Suppresses Inflammation and Triggers Regeneration

GSE307310 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/24 Platform GPL34290
Summary
This study aimed to investigate the transcriptional effects of BMP2 treatment on neonatal mouse cardiomyocytes. Primary cardiomyocytes were treated with either PBS or BMP2 and subjected to bulk RNA sequencing to profile BMP2-induced changes in gene expression. To further dissect the underlying signaling mechanisms, cells were co-treated with the BMP2 receptor inhibitor Dorsomorphin, allowing assessment of the contribution of the canonical SMAD pathway to BMP2-mediated transcriptional regulation. Comparative transcriptomic analysis across treatment groups provides new insights into the role of the BMP2–SMAD signaling axis in cardiomyocyte gene regulation.
Published in
Injury-induced Clusterin(+) cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages
Fan L, Tang Q, Wang Y et al. · Cell stem cell 2025 · PMID 41205597 · doi:10.1016/j.stem.2025.10.008
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Also filed as BioProject PRJNA1315188 and SRA study SRP617635. Searching any of these in the dataset finder brings you back here.

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