TET2 drives myeloid cell fate acquisition through AGO2 modulation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 61 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 61 samples: 20 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307340_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1315269 and SRA study SRP607771. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 61 samples.
How we read this: 20 replicated groups read from 61 sample titles; they account for 61 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9160016 TET2_ChIP_CTRL_r1 TET2_ChIP_CTRL
- GSM9160017 TET2_ChIP_CTRL_r2 TET2_ChIP_CTRL
- GSM9160018 TET2_ChIP_FLAG_r1 TET2_ChIP_FLAG
- GSM9160019 TET2_ChIP_FLAG_r2 TET2_ChIP_FLAG
- GSM9160070 Control, 0 h, r1 Control, 0 h,
- GSM9160071 Control, 0 h, r2 Control, 0 h,
- GSM9160072 Control, 0 h, r3 Control, 0 h,
- GSM9160073 Control, 72 h, r1 Control, 72 h,
- GSM9160074 Control, 72 h, r2 Control, 72 h,
- GSM9160075 Control, 72 h, r3 Control, 72 h,
- GSM9160076 Control, 144 h, r1 Control, 144 h,
- GSM9160077 Control, 144 h, r2 Control, 144 h,
- GSM9160078 Control, 144 h, r3 Control, 144 h,
- GSM9160079 TET2 KD, 0 h, r1 TET2 KD, 0 h,
- GSM9160080 TET2 KD, 0 h, r2 TET2 KD, 0 h,
- GSM9160081 TET2 KD, 0 h, r3 TET2 KD, 0 h,
- GSM9160082 TET2 KD, 72 h, r1 TET2 KD, 72 h,
- GSM9160083 TET2 KD, 72 h, r2 TET2 KD, 72 h,
- GSM9160084 TET2 KD, 72 h, r3 TET2 KD, 72 h,
- GSM9160085 TET2 KD, 144 h, r1 TET2 KD, 144 h,
- GSM9160086 TET2 KD, 144 h, r2 TET2 KD, 144 h,
- GSM9160087 TET2 KD, 144 h, r3 TET2 KD, 144 h,
- GSM9161229 AGO2 KD, Region 1, 0 h, r1 AGO2 KD, Region 1, 0 h,
- GSM9161230 AGO2 KD, Region 1, 0 h, r2 AGO2 KD, Region 1, 0 h,
- GSM9161231 AGO2 KD, Region 1, 0 h, r3 AGO2 KD, Region 1, 0 h,
- GSM9161232 AGO2 KD, Region 1, 72 h, r1 AGO2 KD, Region 1, 72 h,
- GSM9161233 AGO2 KD, Region 1, 72 h, r2 AGO2 KD, Region 1, 72 h,
- GSM9161234 AGO2 KD, Region 1, 72 h, r3 AGO2 KD, Region 1, 72 h,
- GSM9161235 AGO2 KD, Region 1, 144 h, r1 AGO2 KD, Region 1, 144 …
- GSM9161236 AGO2 KD, Region 1, 144 h, r2 AGO2 KD, Region 1, 144 …
- GSM9161237 AGO2 KD, Region 1, 144 h, r3 AGO2 KD, Region 1, 144 …
- GSM9161238 AGO2 KD, Region 2, 0 h, r1 AGO2 KD, Region 2, 0 h,
- GSM9161239 AGO2 KD, Region 2, 0 h, r2 AGO2 KD, Region 2, 0 h,
- GSM9161240 AGO2 KD, Region 2, 0 h, r3 AGO2 KD, Region 2, 0 h,
- GSM9161241 AGO2 KD, Region 2, 72 h, r1 AGO2 KD, Region 2, 72 h,
- GSM9161242 AGO2 KD, Region 2, 72 h, r2 AGO2 KD, Region 2, 72 h,
- GSM9161243 AGO2 KD, Region 2, 72 h, r3 AGO2 KD, Region 2, 72 h,
- GSM9161244 AGO2 KD, Region 2, 144 h, r1 AGO2 KD, Region 2, 144 …
- GSM9161245 AGO2 KD, Region 2, 144 h, r2 AGO2 KD, Region 2, 144 …
- GSM9161246 AGO2 KD, Region 2, 144 h, r3 AGO2 KD, Region 2, 144 …
+ 21 more — browse all 61 samples with per-sample file links →
- GSE305029 TET2 drives myeloid cell fate acquisition through AGO2 modulation [RNA-seq, AGO2 KD transdifferentiation] 27 samples shares tet2, ago2, acquisition, modulation, myeloid, drives, fate
- GSE307201 TET2 drives myeloid cell fate acquisition through AGO2 modulation [RNA-seq, TET2 KD transdifferentiation] 12 samples shares tet2, ago2, acquisition, modulation, myeloid, drives, fate
- GSE241585 Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation 75 samples shares tet2, myeloid
- GSE295935 CNS infiltration by Tet2-mutant peripheral myeloid cells protects from Alzheimer’s Disease 18 samples shares tet2, myeloid
- GSE298864 Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation [MV4-11 RNA-Seq] 12 samples shares tet2, myeloid
- GSE298861 Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation [MV4-11 ATAC-seq] 11 samples shares tet2, myeloid
- GSE307755 Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation 53 samples shares acquisition, drives
- GSE244403 cGAS-STING axis activation drove inflammatory phenotype acquisition of senescent nucleus pulposus cells via p65-mediated transcriptional modulation 12 samples shares acquisition, modulation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.