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Bulk RNA sequencing for gene expression profiling of iPSC-derived liver sinusoidal endothelial cells and arterial endothelial cells

GSE307468 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/31 Platform GPL24014
Summary
Liver sinusoidal endothelial cells (LSECs) line liver sinusoids and regulate exchanges between blood and liver tissue, while maintaining hepatic vascular homeostasis through coagulation control, immune cell recruitment, and barrier function. To compare endotheial lineage markers, we performed bulk RNA-seq analysis of iPSC-derived LSECs (iLSECs) and arterial endotheial cells (iAECs). We here show that venous/LSEC programs in iLSECs (NR2F2, APLNR, CD36; STAB1, LYVE1, FCGR2B), whereas iAECs expressed higher pan-endothelial and arterial markers (PECAM1, CDH5; DLL4, HEY2, NRP1).
Published in
Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids
Kawamura S, Yoneyama Y, Saiki N et al. · Cell reports. Medicine 2025 · PMID 41202806 · doi:10.1016/j.xcrm.2025.102433
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Also filed as BioProject PRJNA1321772 and SRA study SRP618375. Searching any of these in the dataset finder brings you back here.

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