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HIV-1 Tat protein exposure alters the morphological characteristics and gene expression in the primary mouse cortex endothelial cells and human brain microvascular endothelial cells

GSE307481 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/21 Platform GPL18573
Summary
HIV-1-associated neurocognitive disorders (HAND) are highly prevalent in the era of combination of antiretroviral therapies. Recent studies suggest that damage of blood-brain barrier (BBB) may serve as an early biomarker of cognitive dysfunction in people living with HIV. In this study, we focused on endothelial cells, the core component of the BBB, to investigate the effects of HIV-1 transactivator of transcription (Tat) protein on their morphological alterations and gene expression profiles of human brain microvascular endothelial cells (HBMVECs). Our results demonstrated that Tat-exposed HBMVECs showed reduced CD31 expression, increased phalloidin staining intensity, and activation of inflammatory response pathways as revealed by RNA-seq analysis.
Published in
HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells
Quan L, Manabe I, Muramatsu R et al. · Cellular and molecular neurobiology 2025 · PMID 41353488 · doi:10.1007/s10571-025-01640-3
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Also filed as BioProject PRJNA1321817 and SRA study SRP618389. Searching any of these in the dataset finder brings you back here.

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