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HIV-1 Tat protein exposure alters the morphological characteristics and gene expression in the primary mouse cortex endothelial cells and human brain microvascular endothelial cells

GSE307483 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/15 Platform GPL24247
Summary
HIV-1 viral proteins can disrupt tight junctions within the blood-brain barrier (BBB), directly compromising its structural and functional integrity. In this study, we investigated the effects of HIV-1 transactivator of transcription (Tat) protein on mouse prefrontal cortex endothelial cells (ECs) morphological alterations and gene expression profiles. Our results demonstrated that Tat-exposed ECs showed downregulated CD31 expression, increased phalloidin staining intensity, and activation of inflammatory response pathways as revealed by RNA-seq analysis, which is similar to the effects of Tat on human brain microvascular endothelial cells (HBMVECs).
Published in
HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells
Quan L, Manabe I, Muramatsu R et al. · Cellular and molecular neurobiology 2025 · PMID 41353488 · doi:10.1007/s10571-025-01640-3
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Also filed as BioProject PRJNA1321806 and SRA study SRP618379. Searching any of these in the dataset finder brings you back here.

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