Tissue Block-Resolved Spatiotemporal Transcriptomic Atlas of Human Fetal Brainstem Reveals Gene Modules and Paradigms Linked to Neurological Disorders
RNA-seq (gene expression) · human · 107 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 107 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tissue block-resolved developmental transcriptomic atlas of human fetal brainstem reveals gene modules with implications for neurological disordersFrontiers in cell and developmental biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307537_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1321945 and SRA study SRP618496. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 107 more — browse all 107 samples with per-sample file links →
- GSE268599 Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease 146 samples shares spatiotemporal
- GSE68719 mRNA-Seq expression and MS3 proteomics profiling of human post-mortem BA9 brain tissue for Parkinson Disease and neurologically normal individuals 73 samples shares neurological
- GSE292759 High-Throughput Drug Discovery for a Rare Neurological Disorder: Uncovering a Novel Therapeutic Opportunity for the 19q12 Autism Spectrum Disorder [DRUGseq] 68 samples shares neurological
- GSE281535 BrainSTEM: A multi-resolution fetal brain atlas to assess the fidelity of human midbrain cultures 48 samples shares brainstem
- GSE89189 Generation of human microglia-like cells to study neurological disease 43 samples shares neurological
- GSE268650 Spatiotemporal Control of InflammatoryLytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization 18 samples shares spatiotemporal
- GSE267692 Comprehensive serum metabolic snapshots enable diagnosis, prognosis, and monitoring for brainstem gliomas [I] 17 samples shares brainstem
- GSE231585 Gene expression profiling at single nucleus level of microdissected white matter tissue samples of patients with progressive multiple sclerosis and non-neurological disease controls 15 samples shares neurological
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.