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A beneficial environment promotes immune resilience through epigenetic regulation [scRNA-seq]

GSE307573 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/19 Platform GPL21103
Summary
Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, influenced lung immune function in OVA-induced allergic inflammation. FD-exposure reduced allergic lung inflammation and increased monocyte-derived macrophage (MDM) recruitment. scRNA-seq revealed that FD-exposed MDMs had altered gene expression, including dampened Ccl8 and MHCII expression, impairing eosinophil recruitment and antigen presentation. RNA-seq and ATAC-seq confirmed FD-induced epigenetic reprogramming ex-vivo, on bone marrow-derived macrophages. This modulation, seen in both human and murine cells, relied on HDAC activity sustained by PPARγ signaling. These findings suggest that beneficial environmental exposures can reprogram immune cells and may offer a novel strategy for asthma prevention.
Published in
A beneficial environment promotes immune resilience through epigenetic regulation
Dragunas G, Klotz M, Chen S et al. · Science advances 2026 · PMID 41758935 · doi:10.1126/sciadv.ady7317
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Also filed as BioProject PRJNA1322316 and SRA study SRP618671. Searching any of these in the dataset finder brings you back here.

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