Integrative multi-omics deciphers the potential mechanism and microbial biomarkers for lymph node metastasis in colorectal cancer
RNA-seq (gene expression) · human · 66 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 66 samples: 33 × Colon, normal vs 33 × Colon, tumoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative multi-omics deciphers the potential mechanism and microbial biomarkers for lymph node metastasis in colorectal cancerScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308020_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1328601 and SRA study SRP620381. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 66 samples.
How we read this: 2 replicated groups read from 66 sample titles; they account for 66 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9235918 Colon, normal1 Colon, normal
- GSM9235919 Colon, normal2 Colon, normal
- GSM9235920 Colon, normal3 Colon, normal
- GSM9235921 Colon, normal4 Colon, normal
- GSM9235922 Colon, tumor1 Colon, tumo
- GSM9235923 Colon, tumor2 Colon, tumo
- GSM9235924 Colon, tumor3 Colon, tumo
- GSM9235925 Colon, tumor4 Colon, tumo
- GSM9235926 Colon, normal5 Colon, normal
- GSM9235927 Colon, normal6 Colon, normal
- GSM9235928 Colon, normal7 Colon, normal
- GSM9235929 Colon, normal8 Colon, normal
- GSM9235930 Colon, normal9 Colon, normal
- GSM9235931 Colon, normal10 Colon, normal
- GSM9235932 Colon, normal11 Colon, normal
- GSM9235933 Colon, normal12 Colon, normal
- GSM9235934 Colon, normal13 Colon, normal
- GSM9235935 Colon, normal14 Colon, normal
- GSM9235936 Colon, normal15 Colon, normal
- GSM9235937 Colon, normal16 Colon, normal
- GSM9235938 Colon, normal17 Colon, normal
- GSM9235939 Colon, normal18 Colon, normal
- GSM9235940 Colon, normal19 Colon, normal
- GSM9235941 Colon, normal20 Colon, normal
- GSM9235942 Colon, normal21 Colon, normal
- GSM9235943 Colon, normal22 Colon, normal
- GSM9235944 Colon, normal23 Colon, normal
- GSM9235945 Colon, normal24 Colon, normal
- GSM9235946 Colon, normal25 Colon, normal
- GSM9235947 Colon, normal26 Colon, normal
- GSM9235948 Colon, normal27 Colon, normal
- GSM9235949 Colon, normal28 Colon, normal
- GSM9235950 Colon, normal29 Colon, normal
- GSM9235951 Colon, normal30 Colon, normal
- GSM9235952 Colon, normal31 Colon, normal
- GSM9235953 Colon, normal32 Colon, normal
- GSM9235954 Colon, normal33 Colon, normal
- GSM9235955 Colon, tumor5 Colon, tumo
- GSM9235956 Colon, tumor6 Colon, tumo
- GSM9235957 Colon, tumor7 Colon, tumo
+ 26 more — browse all 66 samples with per-sample file links →
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE313035 METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin 67 samples shares metastasis, colorectal
- GSE225182 Gene expression profiling study to identify distinct subtypes in Peritoneal metastasis of colorectal cancer 33 samples shares metastasis, colorectal
- GSE289499 Uncovering Stage-Specific Biomarkers in Colorectal Cancer: RNA-Seq Analysis of Adenoma and Carcinoma Progression 29 samples shares biomarkers, colorectal
- GSE253036 Tumor Cell JAGGED-1 Promotes Lymph Node Metastasis and Predicts Recurrence in Lymph Node Positive Breast Cancer Patients 27 samples shares metastasis, lymph
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.