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scRNA-seq of human CD45+ cells proliferated in the salivary grand or peripheral blood of CD8T cells depleted PBMC-transferred humanized mice

GSE308691 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/01 Platform GPL24676
Summary
We found that the transfer of PBMCs depleted of CD8 T cells into immunodeficient mice resulted in the development of Sjögren's syndrome-like salivary gland symptoms without causing GVHD. To characterize the human immune cells infiltrating the salivary glands, we examined the profiles of human immune cells in the salivary glands or peripheral blood of humanized mice by 10x Genomics single-cell RNA sequencing (scRNA-seq). We revealed that human Tph-like cells co-expressing IL-21 and CXCL13 were highly infiltrated in the salivary glands of CD8 T cell-depleted humanized mice.
Published in
CD8+ T cell depletion promotes human Tph/Tfh cell proliferation and Sjögren syndrome-like symptoms in PBMC-based humanized mice
Piruzyan M, Fujimori S, Sato R et al. · JCI insight 2025 · PMID 41277554 · doi:10.1172/jci.insight.191700
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Also filed as BioProject PRJNA1332536 and SRA study SRP624517. Searching any of these in the dataset finder brings you back here.

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