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DKC1: a robust prognostic factor and potential therapeutic target in Multiple Myeloma

GSE308784 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/15 Platform GPL24676
Summary
Multiple Myeloma (MM) is an incurable plasma cell malignancy. Dyskerin pseudouridine synthase 1 (DKC1), a nucleolar protein, is essential for RNA modification and cellular homeostasis, yet its role in MM remains unclear. Here, we report that elevated DKC1 expression independently predicted poor outcomes in MM and further refined prognostic stratification beyond the ISS system. Functional assays showed that DKC1 promoted MM cell proliferation, survival, and colony formation, whereas DKC1 knockdown or pharmacological inhibition of DKC1 by pyrazofurin inhibited proliferation and colonies, induced apoptosis, and suppressed tumor growth in xenografts. Mechanistically, DKC1 promotes tumor progression by stabilizing ATF5 mRNA through pseudouridylation, a direct post-transcriptional mechanism evidenced by site-specific pseudouridine mapping. Together, these findings highlight DKC1 as both a critical prognostic biomarker and a promising therapeutic target.
Published in
DKC1: a robust prognostic factor and potential therapeutic target in multiple myeloma
Sun C, Cheng L, Li A et al. · Journal of translational medicine 2026 · PMID 41781996 · doi:10.1186/s12967-026-07916-6
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Also filed as BioProject PRJNA1332719 and SRA study SRP624934. Searching any of these in the dataset finder brings you back here.

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