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Impact of ECTV C15 expression on the development of CD8+ effector T cells

GSE308808 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/12 Platform GPL34290
Summary
Orthopoxviruses, such as variola and Mpox, encode a myriad of immunomodulatory proteins to promote pathogenesis. One notable family is the B22 family of proteins, which are highly conserved surface glycoproteins that potently inhibit T cell activation in vitro and ex vivo. However, there has been limited work investigating the impact of B22 proteins on both CD4+ and CD8+ T cell responses in vivo. Therefore, we used ectromelia (ECTV) as a natural host-pathogen model to investigate the impact of its B22 protein, C15, on T cell responses in vivo. To broadly investigate the impact of C15 on CD8+ effector (CD62L-CD44+) T cell development, we performed bulk RNA-seq on splenic CD8+ effector T cells 7 days post-infection with either WT ECTV or ECTV∆C15.
Published in
Conditional T and NK cell antagonism by a giant and highly conserved orthopoxvirus virulence factor
Carro SD, Hedgepeth EJ, Lucero-Sanchez C et al. · Research square 2026 · PMID 41674806 · doi:10.21203/rs.3.rs-8672980/v1
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Also filed as BioProject PRJNA1332742 and SRA study SRP625155. Searching any of these in the dataset finder brings you back here.

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