Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens
RNA-seq (gene expression) · mouse · 95 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 95 samples: 95 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Alcohol dependence-induced astrocyte immune activation in the nucleus accumbensNeurobiology of disease · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308880_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1333313 and SRA study SRP625487. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 95 sample titles: 95 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9254882 NAc, C17, Female, Dependent, Input
- GSM9254883 NAc, C17, Female, Dependent, IP
- GSM9254884 NAc, G22, Female, Dependent, Input
- GSM9254885 NAc, G22, Female, Dependent, IP
- GSM9254886 NAc, I01, Female, non-Dependent, Input
- GSM9254887 NAc, I01, Female, non-Dependent, IP
- GSM9254888 NAc, I02, Female, Dependent, Input
- GSM9254889 NAc, I02, Female, Dependent, IP
- GSM9254890 NAc, I03, Male, non-Dependent, Input
- GSM9254891 NAc, I03, Male, non-Dependent, IP
- GSM9254892 NAc, I04, Female, non-Dependent, Input
- GSM9254893 NAc, I04, Female, non-Dependent, IP
- GSM9254894 NAc, I05, Female, Dependent, Input
- GSM9254895 NAc, I05, Female, Dependent, IP
- GSM9254896 NAc, I06, Male, non-Dependent, Input
- GSM9254897 NAc, I06, Male, non-Dependent, IP
- GSM9254898 NAc, I07, Male, Dependent, Input
- GSM9254899 NAc, I07, Male, Dependent, IP
- GSM9254900 NAc, I08, Female, non-Dependent, Input
- GSM9254901 NAc, I08, Female, non-Dependent, IP
- GSM9254902 NAc, I09, Female, Dependent, Input
- GSM9254903 NAc, I09, Female, Dependent, IP
- GSM9254904 NAc, I10, Male, non-Dependent, Input
- GSM9254905 NAc, I11, Male, Dependent, Input
- GSM9254906 NAc, I11, Male, Dependent, IP
- GSM9254907 NAc, I12, Female, non-Dependent, Input
- GSM9254908 NAc, I12, Female, non-Dependent, IP
- GSM9254909 NAc, I13, Female, Dependent, Input
- GSM9254910 NAc, I13, Female, Dependent, IP
- GSM9254911 NAc, I14, Male, non-Dependent, Input
- GSM9254912 NAc, I15, Male, Dependent, Input
- GSM9254913 NAc, I15, Male, Dependent, IP
- GSM9254914 NAc, I16, Female, non-Dependent, Input
- GSM9254915 NAc, I16, Female, non-Dependent, IP
- GSM9254916 NAc, J01, Female, Naïve, Input
- GSM9254917 NAc, J01, Female, Naïve, IP
- GSM9254918 NAc, J02, Male, Naïve, Input
- GSM9254919 NAc, J02, Male, Naïve, IP
- GSM9254920 NAc, J03, Male, non-Dependent, Input
- GSM9254921 NAc, J03, Male, non-Dependent, IP
+ 55 more — browse all 95 samples with per-sample file links →
- GSE248222 Impact of Maternal Immune Activation and Sex on Placental and Fetal Brain Cytokine and Gene Expression Profiles in a Preclinical Model of Neurodevelopmental Disorders 64 samples shares activation
- GSE322775 Coordinated immune activation following KRAS inhibition reveals molecular pathways that potentiate and limit anti-tumor immunity 47 samples shares activation
- GSE302070 Heterogeneity and Homogeneity in Treg responses to Interleukin-2 [RNAseq2: Differential activation of Immune cell types by IL2-Immunocytokines] 45 samples shares activation
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares activation
- GSE287323 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination 19 samples shares astrocyte
- GSE313021 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [scRNA-seq] 16 samples shares activation
- GSE317949 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [APCM_BulkRNASeq_OT1] 15 samples shares activation
- GSE303181 STC-1 Attenuates Scar Formation via PI3K/AKT Pathway Activation and Immune Modulation 12 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.