Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice [RNA-seq AVITI]
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in miceToxicological sciences : an official journal of the Society of Toxicology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309115_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1333980 and SRA study SRP626432. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9261386 WT 0hr 1 WT 0h
- GSM9261387 WT 0hr 2 WT 0h
- GSM9261388 WT 0hr 3 WT 0h
- GSM9261389 KO 0hr 1 KO 0h
- GSM9261390 KO 0hr 2 KO 0h
- GSM9261391 KO 0hr 3 KO 0h
- GSM9261392 WT 1hr 1 WT 1h
- GSM9261393 WT 1hr 2 WT 1h
- GSM9261394 WT 1hr 3 WT 1h
- GSM9261395 KO 1hr 1 KO 1h
- GSM9261396 KO 1hr 2 KO 1h
- GSM9261397 KO 1hr 3 KO 1h
- GSM9261398 WT 3hr 1 WT 3h
- GSM9261399 WT 3hr 2 WT 3h
- GSM9261400 WT 3hr 3 WT 3h
- GSM9261401 KO 3hr 1 KO 3h
- GSM9261402 KO 3hr 2 KO 3h
- GSM9261403 KO 3hr 3 KO 3h
- GSM9261404 WT 12hr 1 WT 12h
- GSM9261405 WT 12hr 2 WT 12h
- GSM9261406 WT 12hr 3 WT 12h
- GSM9261407 KO 12hr 1 KO 12h
- GSM9261408 KO 12hr 2 KO 12h
- GSM9261409 KO 12hr 3 KO 12h
- GSE309118 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice 42 samples shares egfr, acetaminophen-induced, hepatocyte-specific, attenuates, epidermal, receptor, deletion
- GSE309117 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice [RNA-seq Illumina] 18 samples shares egfr, acetaminophen-induced, hepatocyte-specific, attenuates, epidermal, receptor, deletion
- GSE305543 Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice 18 samples shares acetaminophen-induced, hepatocyte-specific, deletion
- GSE301098 Gene expression analysis in hepatocytes in response to hepatocyte-specific Succinate Receptor 1 (SUCNR1) deletion 6 samples shares hepatocyte-specific, receptor, deletion
- GSE287351 Bile acids bind to exposed cavities in the glucocorticoid receptor 24 samples shares aviti, receptor
- GSE266959 Epidermal Growth Factor Rejuvenates Aged Hematopoietic Stem Cells [EGFR Dominant Negative] 6 samples shares egfr, epidermal
- GSE279941 Deletion of Egfr in myeloid cells counteracts an immuno-suppressive tumor microenvironment in CRC 4 samples shares egfr, deletion
- GSE328680 Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in MASLD Progression 12 samples shares hepatocyte-specific, deletion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.