GEO series
Disruption of broad H3K9me3 domains and chromatin folding regulates oncogenic transcriptional milieu in ATRX-deficient gliomas [ChIP-seq]
GSE309141
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
14 samples
2026/07/01
GPL19057
Summary
To further understand the downstream epigenomic dysfunction induced by ATRX deficiency, we compared genome-wide chromatin-state maps of Atrx+ and Atrx- primary murine neuroepithelial progenitors (mNPCs). This ChIP–seq analysis revealed major differences in the localization of heterochromatin repressive marks H3K9me3 and H3K27me3. Specifically, we identified peculiar locations in the genome displaying H3K9me3 depletion and gain of H3K27me3 upon Atrx inactivation.
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Paper (PMID 42339622) ↗
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