Acute Arrhythmias in a Long-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHADD) Mouse Model
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × LCHADD fem V vs 3 × LCHADD male V vs 3 × WT fem V vs 3 × WT male VGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Acute arrhythmias in a long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mouse modelAmerican journal of physiology. Heart and circulatory physiology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309626_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1336640 and SRA study SRP629979. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9270686 LCHADD fem V1 LCHADD fem V
- GSM9270687 LCHADD fem V2 LCHADD fem V
- GSM9270688 LCHADD fem V3 LCHADD fem V
- GSM9270689 LCHADD male V2 LCHADD male V
- GSM9270690 LCHADD male V1 LCHADD male V
- GSM9270691 LCHADD male V3 LCHADD male V
- GSM9270692 WT fem V1 WT fem V
- GSM9270693 WT fem V2 WT fem V
- GSM9270694 WT fem V3 WT fem V
- GSM9270695 WT male V3 WT male V
- GSM9270696 WT male V2 WT male V
- GSM9270697 WT male V1 WT male V
- GSE282980 Alpha-ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia [RN2_shOGDH] 24 samples shares dehydrogenase, acute
- GSE317551 Aldehyde dehydrogenase 2 deficiency exacerbates alcohol-associated liver fibrosis 15 samples shares dehydrogenase, deficiency
- GSE282977 Alpha-ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia [KL974_shOGDH] 14 samples shares dehydrogenase, acute
- GSE263778 One deficiency, different outcomes: Succinate dehydrogenase loss in chromaffin cell vs. fibroblast models of paraganglioma 12 samples shares dehydrogenase, deficiency
- GSE296978 H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (RNA-seq) 6 samples shares dehydrogenase, deficiency
- GSE289995 6-phosphogluconate dehydrogenase blockade in T Cells mitigates acute graft-versus-host disease while preserving graft-versus-tumor activity 2 samples shares dehydrogenase, acute
- GSE296977 H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ChIP-seq) 24 samples shares dehydrogenase, deficiency
- GSE296976 H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ATAC-seq) 8 samples shares dehydrogenase, deficiency
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.