Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson’s Disease
RNA-seq (gene expression) · mouse · 48 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 48 samples: 48 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson's DiseasebioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309633_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1336649 and SRA study SRP629993. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 48 sample titles: 48 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9270732 JJ0400, control, Refeeding
- GSM9270733 JJ0388, control, Refeeding
- GSM9270734 JJ0380, control, Refeeding
- GSM9270735 JJ0419, control, Refeeding
- GSM9270736 JJ0420, Grin1_KO, Refeeding
- GSM9270737 JJ0421, Grin1_KO, Refeeding
- GSM9270738 JJ0387, Grin1_KO, Refeeding
- GSM9270739 JJ0399, Grin1_KO, Refeeding
- GSM9270740 JJ0422, Grin1_KO, No Restriction
- GSM9270741 JJ0378, control, No Restriction
- GSM9270742 JJ0379, control, Post-Restriction
- GSM9270743 JJ0390, control, Post-Restriction
- GSM9270744 JJ0389, Grin1_KO, Post-Restriction
- GSM9270745 JJ0344, control, No Restriction
- GSM9270746 JJ0376, Grin1_KO, No Restriction
- GSM9270747 JJ0354, Grin1_KO, No Restriction
- GSM9270748 JJ0459, control, Post-Restriction
- GSM9270749 JJ0353, Grin1_KO, Post-Restriction
- GSM9270750 JJ0331, Grin1_KO, Post-Restriction
- GSM9270751 JJ0377, Grin1_KO, Post-Restriction
- GSM9270752 JJ0328, control, Refeeding
- GSM9270753 JJ0329, control, Refeeding
- GSM9270754 JJ0351, control, Refeeding
- GSM9270755 JJ0392, control, Refeeding
- GSM9270756 JJ0345, Grin1_KO, Refeeding
- GSM9270757 JJ0343, Grin1_KO, Refeeding
- GSM9270758 JJ0500, Grin1_KO, Refeeding
- GSM9270759 JJ0391, Grin1_KO, Refeeding
- GSM9270760 JJ0415, control, No Restriction
- GSM9270761 JJ0455, control, No Restriction
- GSM9270762 JJ0457, control, No Restriction
- GSM9270763 JJ0405, Grin1_KO, No Restriction
- GSM9270764 JJ0454, Grin1_KO, No Restriction
- GSM9270765 JJ0416, Grin1_KO, No Restriction
- GSM9270766 JJ0444, control, No Restriction
- GSM9270767 JJ0436, control, No Restriction
- GSM9270768 JJ0358, control, No Restriction
- GSM9270769 JJ0434, Grin1_KO, No Restriction
- GSM9270770 JJ0442, Grin1_KO, No Restriction
- GSM9270771 JJ0443, Grin1_KO, Post-Restriction
+ 8 more — browse all 48 samples with per-sample file links →
- GSE285508 A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease 36 samples shares dopaminergic, vulnerable, parkinson, subtype, neuron
- GSE252967 Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease 20 samples shares dopaminergic, parkinson, neuron
- GSE276319 The ion channel mechanisms of the subthreshold inward depolarizing currents in the VTA dopaminergic neurons and their roles in the depression-like behavior 45 samples shares dopaminergic, neuron
- GSE291694 Stem cell-derived human glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes 42 samples shares glutamatergic, neuron
- GSE305208 Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption 30 samples shares disruption, vulnerable
- GSE285556 Spatiotemporal Proteomic and Transcriptomic Landscape of DAT+ Dopaminergic Neurons Development and Function 27 samples shares dopaminergic, neuron
- GSE333494 Hippocampal CA3 Nex+ neuronal TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways 26 samples shares sex-dependent, neuron
- GSE269898 Neddylation regulate the development of glutamatergic neurons 23 samples shares glutamatergic, neuron
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.