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Adenosine - a regulator of human testicular peritubular cells

GSE309639 Homo sapiens Expression profiling by high throughput sequencing 3 samples Submitted 2026/07/01 Platform GPL24676
Summary
Extracellular purines, particularly ATP and adenosine, are key regulators of physiological and pathophysiological processes throughout the human body. Despite their systemic importance, the specific roles of purinergic signaling in the human testis and their potential relevance for male fertility, are not well studied. As these processes cannot be readily studied in vivo, human testicular peritubular cells (HTPCs), which form the wall of seminiferous tubules, provide a unique and accessible in vitro model. HTPCs were isolated from testicular samples and cultured. Transcriptional profiles of adenosine-treated cells were analyzed using scRNA-seq, revealing strong upregulation of IL33, STAR, HIF1A, and others. Pathways linked to cell communication, migration and inflammation were enriched in HTPCs following adenosine treatment.
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Also filed as BioProject PRJNA1336657 and SRA study SRP630012. Searching any of these in the dataset finder brings you back here.

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