GEO series
Transcriptomic analysis of pathway activation after decitabine treatment in EBV+ vs EBV- gastric cancer [RNA-Seq]
GSE309938
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2025/11/14
GPL18573
Summary
Epstein-Barr virus associated gastric cancer (EBVaGC) accounts for ∼9–10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA. Targeting this aberrant methylation may be a potential therapeutic strategy. EBV ⁺ gastric cancer cell lines (YCCEL1, SNU719) and EBV ⁻ lines (AGS, SNU16, HGC27) were treated with a DNA methyl-transferase inhibitor (DNMT), decitabine (DCB), for three days followed by RNA sequencing to identify EBV-specific responses.
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Paper (PMID 41665354) ↗
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